About the Calculator
In the United States, more than 80% of tuberculosis (TB) cases are the result of reactivated latent TB infection. Targeted screening and treatment of latent tuberculosis infection (LTBI) in selected populations is endorsed as a costeffective, necessary step to TB elimination in the U.S.
The following calculator is intended to help clinicians responsible for TB control to optimize resources related to TB prevention. The calculator allows cost comparisons between diagnostic methods and treatment options, while estimating the program costs of screening populations for latent tuberculosis infection (LTBI).
Please enter the estimated number of individuals to be screened for LTBI 


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Treatment Cost Comparison  

Selfadministered Treatment  DOPT Treatment  
TST Screening  IGRA Screening  TST Screening  IGRA Screening  
Treatment cost per completed treatment  
Total diagnostic and screening cost  
The number of TB cases prevented  
The cost per TB case prevented  
Cost to treat one potential case of active TB  
Total costs to treat all active TB potentially developing from screened population  
Diagnostic Cost Comparison  
TST Screening  IGRA Screening  
True Positive  
False Positive  
True Negative  
False Negative  
Number needed to screen for 1 true LTBI+ diagnosis  
Cost per completed screen on LTBI+ patient  
Cost per completed screen for LTBI patient  
Cost per true LTBI diagnosis  
Surveilance Cost Comparison  
TST Screening  IGRA Screening  
Total surveillance cost  
Total surveillance cost per true positive  
Number of true positives per $1000 of surveillance cost  
Total Program Costs  
Selfadministered Treatment  DOPT Treatment  
TST Screening  IGRA Screening  TST Screening  IGRA Screening  
Total program cost (total surveillance cost + cost to treat all positives)  
Total cost to find and treat one infected person  1159.29  2980.18  2907.58  4728.47 